Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170782 | 0.79 | — | — | |
| SCHEMBL8310366 | 0.78 | ADRA2A (0.48) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL8824678 | 0.77 | TAAR1 (0.47) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL14520090 | 0.76 | GAA (0.50) | ALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL8819697 | 0.72 | FDPS (0.48) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL7342758 | 0.72 | FDPS (0.48) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL14520070 | 0.72 | GAA (0.58) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL2403988 | 0.71 | TBXAS1 (0.44) | FDPSTBXAS1ADRA2AADRA2CADRA1D | |
| SCHEMBL708660 | 0.70 | ADRA2A (0.56) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL241675 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |