Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 6/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612297 | 0.95 | FDPS (0.47) | FDPSKCNA5GPR132CYP1A2CYP3A4 | |
| SCHEMBL7610487 | 0.92 | ALPL (0.40) | FDPSCYP3A4ALDH1A1MAPTHTT | |
| SCHEMBL7610481 | 0.80 | FDPS (0.44) | FDPSKCNA5GPR132CYP1A2CYP3A4 | |
| SCHEMBL7603936 | 0.78 | FDPS (0.43) | FDPSKCNA5GPR132CYP1A2CYP3A4 | |
| SCHEMBL7609429 | 0.75 | FDPS (0.46) | FDPSKCNA5GPR132CYP1A2CYP3A4 | |
| SCHEMBL7605187 | 0.74 | FDPS (0.45) | FDPSKCNA5GPR132CYP1A2CYP3A4 | |
| SCHEMBL5497372 | 0.73 | KCNA5 (0.48) | KCNA5CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7607667 | 0.73 | LMNA (0.40) | LMNAHTT | |
| SCHEMBL6178344 | 0.72 | CYP1A2 (0.51) | KCNA5CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7607525 | 0.72 | MMP1 (0.37) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |