Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 1/20 | 0.50 |
| ▸ | ME1 | P48163 | 1/20 | 0.50 |
| ▸ | ME3 | Q16798 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438080 | 0.91 | MAPT (0.71) | MAPTDRD4KDM4EGAAKMT2A | |
| SCHEMBL28758087 | 0.89 | KDM4E (0.61) | MAPTKDM4EGAAKMT2ANPC1 | |
| SCHEMBL870704 | 0.82 | HTR3E (0.70) | MAPTDRD4KDM4EGAACHIA | |
| SCHEMBL29998630 | 0.82 | HTR3E (0.70) | MAPTDRD4KDM4EGAACHIA | |
| SCHEMBL23655782 | 0.82 | ADRB1 (0.53) | MAPTKDM4EGAAKMT2AADRB1 | |
| SCHEMBL178275 | 0.82 | ALDH1A1 (0.63) | MAPTKDM4EGAAKMT2AHTR3A | |
| SCHEMBL12128002 | 0.82 | KDM4E (0.63) | MAPTDRD4KDM4ESIGMAR1NPC1 | |
| SCHEMBL11164683 | 0.81 | SIGMAR1 (0.51) | MAPTDRD4KDM4EGAAKMT2A | |
| SCHEMBL24715763 | 0.81 | KDM4E (0.57) | MAPTKDM4EGAAKMT2ANPC1 | |
| SCHEMBL2056142 | 0.81 | KDM4E (0.57) | MAPTKDM4EGAAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210340-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR UTILIZATION AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001014355-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR UTILIZATION AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-01 | — | — | WO | disclosed |