Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24051897 | 0.84 | MTNR1A (0.49) | HSP90AA1MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL8138023 | 0.84 | EGFR (0.59) | EGFRHSP90AB1KDM4EALDH1A1GLA | |
| SCHEMBL19332330 | 0.84 | HSP90AA1 (0.54) | HSP90AA1MTNR1AMTNR1BBCL2BCL2L1 | |
| SCHEMBL19332225 | 0.80 | LMNA (0.51) | ALDH1A1GAALMNA | |
| SCHEMBL25346475 | 0.79 | PTPN1 (0.57) | HSP90AB1BCL2BCL2L1KDM4EALDH1A1 | |
| SCHEMBL28169190 | 0.79 | KDM4E (0.44) | HSP90AA1KDM4EALDH1A1LMNASLC7A5 | |
| SCHEMBL10906375 | 0.79 | HSP90AB1 (0.53) | ALOX5HSP90AB1BCL2BCL2L1KDM4E | |
| SCHEMBL11764362 | 0.79 | ALOX5 (0.74) | HSP90AA1ALOX5BCL2BCL2L1HSD17B3 | |
| SCHEMBL27474234 | 0.78 | EGFR (0.54) | EGFRHSP90AB1KDM4EALDH1A1GLA | |
| SCHEMBL7042369 | 0.78 | MTNR1A (0.64) | HSP90AA1MTNR1AMTNR1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |