Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.84 |
| ▸ | MEN1 | O00255 | 5/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.81 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.81 |
| ▸ | TP53 | P04637 | 1/20 | 0.81 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.81 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.78 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.78 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.72 |
| ▸ | TAS2R31 | P59538 | 1/20 | 0.72 |
| ▸ | FLT3 | P36888 | 2/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30375958 | 1.00 | HDAC6 (0.84) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| SCHEMBL8062995 | 0.93 | CYP1A1 (0.88) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| Eupatilin SCHEMBL29568655 | 0.91 | HDAC6 (1.00) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| Eupatilin SCHEMBL1033509 | 0.91 | HDAC6 (1.00) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| Eupatilin SCHEMBL29926197 | 0.91 | HDAC6 (1.00) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| SCHEMBL8069068 | 0.91 | HDAC6 (0.74) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| Sinensetin SCHEMBL29549544 | 0.90 | ABCB1 (1.00) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| Sinensetin SCHEMBL29700880 | 0.90 | ABCB1 (1.00) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| Sinensetin SCHEMBL621101 | 0.90 | ABCB1 (1.00) | HDAC6MEN1KMT2AABCB1ABCG2 | |
| SCHEMBL8052853 | 0.89 | HDAC6 (0.71) | HDAC6MEN1KMT2AABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111836808-B | Novel compound for preventing, alleviating or treating fibrosis or nonalcoholic steatohepatitis and composition comprising the same as active ingredient | 欧斯特奥纽罗根有限公司 | 2023-04-28 | — | — | CN | disclosed |
| EP-3760626-B1 | NOVEL COMPOUND AND COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING FIBROSIS OR NONALCOHOLIC STEATOHEPATITIS COMPRISING SAME AS ACTIVE INGREDIENT | OSTEONEUROGEN INC (KR) | 2022-05-18 | — | — | EP | disclosed |
| EP-3760626-A1 | NOVEL COMPOUND AND COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING FIBROSIS OR NONALCOHOLIC STEATOHEPATITIS COMPRISING SAME AS ACTIVE INGREDIENT | Osteoneurogen Inc. (KR) | 2021-01-06 | — | — | EP | disclosed |
| CN-111836808-A | Novel compound for preventing, alleviating or treating fibrosis or nonalcoholic steatohepatitis and composition comprising same as active ingredient | 欧斯特奥纽罗根有限公司 | 2020-10-27 | — | — | CN | disclosed |
| US-20190263789-A1 | SUBSTITUTED CHROMENES FOR TREATMENT OF FIBROSIS OR NON-ALCOHOLIC STEATOHEPATITIS | OSTEONEUROGEN INC. (KR) | 2019-08-29 | — | — | US | disclosed |
| US-10370364-B1 | Substituted chromenes for treatment of fibrosis or non-alcoholic steatohepatitis | OSTEONEUROGEN INC. (KR) | 2019-08-06 | — | — | US | disclosed |
| WO-2017146332-A1 | NOVEL USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING FIBROSIS BY USING EPITHELIAL-MESENCHYMAL TRANSITION INHIBITORY ACTIVITY THEREOF | (주)오스티오뉴로젠 | 2017-08-31 | — | — | WO | disclosed |
| US-20120029066-A1 | USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS | TAIPEI MEDICAL UNIVERSITY (TW) | 2012-02-02 | — | — | US | disclosed |
| EP-0915864-B1 | GASTROPROTECTIVE FLAVONE/FLAVANONE COMPOUNDS WITH THERAPEUTIC EFFECT ON INFLAMMATORY BOWEL DISEASE | DONG A PHARM CO LTD (KR) | 2002-09-04 | — | — | EP | disclosed |
| US-6025387-A | Gastroprotective flavone/flavanone compounds with therapeutic effect on inflammatory bowel disease | DONG A PHARMACEUTICAL CO., LTD. (KR) | 2000-02-15 | — | — | US | disclosed |
| EP-0915864-A1 | GASTROPROTECTIVE FLAVONE/FLAVANONE COMPOUNDS WITH THERAPEUTIC EFFECT ON INFLAMMATORY BOWEL DISEASE | Dong A Pharmaceutical Co. Ltd. (KR) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004541-A1 | GASTROPROTECTIVE FLAVONE/FLAVANONE COMPOUNDS WITH THERAPEUTIC EFFECT ON INFLAMMATORY BOWEL DISEASE | DONG A PHARMACEUTICAL CO., LTD. (KR) | 1998-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370364-B1 | Substituted chromenes for treatment of fibrosis or non-alcoholic steatohepatitis | CYP7A1, NR1H3, CES1 | HDAC6 1658/4885MEN1 4258/4885KMT2A 2738/4885 |
| US-20190263789-A1 | SUBSTITUTED CHROMENES FOR TREATMENT OF FIBROSIS OR NON-ALCOHOLIC STEATOHEPATITIS | VIM, HNF4A, CDH1 | HDAC6 1186/4885MEN1 3681/4885KMT2A 2425/4885 |
| US-20120029066-A1 | USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS | HTR2C, GRIN2C, HTR5A | HDAC6 4158/4885MEN1 4859/4885KMT2A 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.