Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940669 | 0.88 | ALDH1A1 (0.86) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16140794 | 0.83 | CYP1A2 (0.55) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1205031 | 0.83 | CYP1A2 (0.71) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| Nitrobenzene SCHEMBL28033286 | 0.80 | CYP1A2 (0.59) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL7598139 | 0.79 | SMN1; SMN2 (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2KCNH2 | |
| SCHEMBL7602000 | 0.78 | TSHR (0.50) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9415962 | 0.77 | KCNH2 (0.57) | MAPTKCNH2TSHRHSD17B10HTT | |
| SCHEMBL9415961 | 0.77 | KCNH2 (0.57) | MAPTKCNH2TSHRHSD17B10HTT | |
| SCHEMBL28943086 | 0.77 | KCNH2 (0.57) | MAPTKCNH2TSHRHSD17B10HTT | |
| SCHEMBL10822735 | 0.77 | KCNH2 (0.57) | MAPTKCNH2TSHRHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | NOS1, NOS2, NOS3 | ALDH1A1 449/4885LMNA 1976/4885CYP1A2 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.