Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 11/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667240 | 0.81 | P2RX7 (0.47) | HRH3SUV39H2PIM1PIM3PIM2 | |
| SCHEMBL7554643 | 0.81 | WNT3A (0.48) | PSMD14USP2MMP2 | |
| SCHEMBL6486070 | 0.77 | SUV39H2 (0.50) | SUV39H2PIM1PIM3PIM2 | |
| SCHEMBL7242505 | 0.77 | SUV39H2 (0.50) | SUV39H2HDAC3HDAC1HDAC2PIM1 | |
| SCHEMBL25453975 | 0.76 | SUV39H2 (0.55) | SUV39H2PIM1PIM3PIM2 | |
| SCHEMBL7554394 | 0.75 | GFER (0.49) | HRH3PSMD14USP2MMP2 | |
| SCHEMBL7235725 | 0.75 | SUV39H2 (0.48) | SUV39H2HDAC3HDAC1HDAC2PIM1 | |
| SCHEMBL1350984 | 0.75 | SUV39H2 (0.48) | SUV39H2PIM1PIM3PIM2 | |
| SCHEMBL1350982 | 0.75 | SUV39H2 (0.48) | SUV39H2PIM1PIM3PIM2 | |
| SCHEMBL7235706 | 0.74 | HPGD (0.48) | SUV39H2PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |