Sugi Predict

Sugi Predict / Compounds / SCHEMBL761480

SCHEMBL761480

SCHEMBL761480

O=C(Cl)C(=O)c1c[nH]c2ccccc12

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR84 Q9NQS5 1/20 0.67
▸ ALDH1A1 P00352 2/20 0.62
▸ PBRM1 Q86U86 1/20 0.62
▸ ATM Q13315 1/20 0.62
▸ KMT2A Q03164 4/20 0.59
▸ MEN1 O00255 3/20 0.59
▸ NPC1 O15118 1/20 0.59
▸ RAB9A P51151 1/20 0.59
▸ NR4A2 P43354 2/20 0.57
▸ MAPK1 P28482 1/20 0.57
▸ CREBBP Q92793 1/20 0.57
▸ GABRA1 P14867 4/20 0.56
▸ GABRG2 P18507 4/20 0.56
▸ GABRB3 P28472 4/20 0.56
▸ GABRA3 P34903 4/20 0.56
▸ GABRA2 P47869 4/20 0.56
▸ GABRB2 P47870 4/20 0.56
▸ GABRP O00591 3/20 0.56
▸ GABRD O14764 3/20 0.56
▸ GABRB1 P18505 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504738 1.00 GPR84 (0.67) GPR84ALDH1A1PBRM1ATMKMT2A
Hydrochloric Acid SCHEMBL6099324 0.98 GPR84 (0.65) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL4954977 0.88 GPR84 (0.77) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL30353966 0.85 GPR84 (0.71) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL72811 0.85 GPR84 (0.71) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL369704 0.83 GPR84 (0.69) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL29465573 0.83 GPR84 (0.69) GPR84ALDH1A1PBRM1ATMKMT2A
Hydrochloric Acid SCHEMBL6073132 0.83 GPR84 (0.69) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL11140928 0.83 GPR84 (0.59) GPR84ALDH1A1PBRM1ATMKMT2A
SCHEMBL11140920 0.83 GPR84 (0.59) GPR84ALDH1A1PBRM1ATMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068703-A1 METHOD FOR PRODUCING DURUMAMIDE 동국대학교 와이즈캠퍼스 산학협력단 2023-04-27 — — WO claimed
US-20160368928-A1 MELAMPOMAGNOLIDE B DERIVATIVES BIOVENTURES, LLC 2016-12-22 — — US claimed
US-20150203508-A1 MELAMPOMAGNOLIDE B DERIVATIVES BIOVENTURES, LLC 2015-07-23 — — US claimed
US-20070093531-A1 Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them ELBION AG 2007-04-26 — — US claimed
US-7166637-B2 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them ELBION AG (DE) 2007-01-23 — — US claimed
WO-2007000289-A1 NITRO-SUBSTITUTED HYDROXYINDOLES,THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE 4, AND PROCESSES FOR PREPARING THEM ELBION AG (DE) 2007-01-04 — — WO claimed
US-20060293362-A1 Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them ELBION AG (DE) 2006-12-28 — — US claimed
EP-1562584-A1 NOVEL HYDROXYINDOLES, USE AS INHIBITORS OF PHOSPHODIESTERASE 4 AND METHOD FOR PRODUCTION THEREOF Elbion AG (DE) 2005-08-17 — — EP claimed
US-20040147759-A1 Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them ELBION AG (DE) 2004-07-29 — — US claimed
WO-2004045607-A1 NOVEL HYDROXYINDOLES, USE AS INHIBITORS OF PHOSPHODIESTERASE 4 AND METHOD FOR PRODUCTION THEREOF ELBION AG (DE) 2004-06-03 — — WO claimed
JP-11228570-A — — None — — JP disclosed
JP-11199582-A — — None — — JP disclosed
EP-4710923-A2 INDOLE AHR INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2026-03-18 — — EP disclosed
EP-3612030-B1 INDOLE AHR INHIBITORS AND USES THEREOF IKENA ONCOLOGY INC (US) 2025-12-24 — — EP disclosed
US-20250122205-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2025-04-17 — — US disclosed
US-4073911-A ANTIHYPERTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1978-02-14 — — US disclosed
US-4046900-A TRANQUILIZERS, HYPOTENSIVES, ANALGESICS AMERICAN HOECHST CORPORATION (US) 1977-09-06 — — US disclosed
US-4031221-A ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS AMERICAN HOECHST CORPORATION (US) 1977-06-21 — — US disclosed
US-3997539-A HYPOTENSIVE, TRANQUILIZER AMERICAN HOECHST CORPORATION (US) 1976-12-14 — — US disclosed
US-RE28973-E PARKINSON'S DISEASE A. H. ROBINS COMPANY, INCORPORATED (US) 1976-09-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147759-A1 Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them PDE4B, PDE4A, PDE4D GPR84 863/4885ALDH1A1 1187/4885PBRM1 4087/4885
US-20150203508-A1 MELAMPOMAGNOLIDE B DERIVATIVES CMBL, MGMT, MMAB GPR84 1303/4885ALDH1A1 2275/4885PBRM1 663/4885
US-20160368928-A1 MELAMPOMAGNOLIDE B DERIVATIVES CMBL, MGMT, MMAB GPR84 1303/4885ALDH1A1 2275/4885PBRM1 663/4885
US-20250122205-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 GPR84 100/4885ALDH1A1 316/4885PBRM1 4784/4885
US-20060293362-A1 Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them PDE4A, PDE4B, PDE4D GPR84 1178/4885ALDH1A1 1024/4885PBRM1 3818/4885
US-20070093531-A1 Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them PDE4B, PDE4A, PDE4D GPR84 1601/4885ALDH1A1 1815/4885PBRM1 4242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.