Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.79 |
| ▸ | MMP9 | P14780 | 11/20 | 0.79 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.79 |
| ▸ | MMP13 | P45452 | 4/20 | 0.70 |
| ▸ | MMP1 | P03956 | 3/20 | 0.70 |
| ▸ | MMP3 | P08254 | 3/20 | 0.70 |
| ▸ | MMP7 | P09237 | 3/20 | 0.70 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | CTSS | P25774 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615081 | 1.00 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL7615070 | 0.89 | MMP2 (0.65) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL6545297 | 0.89 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL32691761 | 0.89 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL1920507 | 0.89 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL28690186 | 0.84 | TDP1 (0.72) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL28690184 | 0.84 | TDP1 (0.72) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL9710605 | 0.83 | MMP2 (0.61) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL7300647 | 0.83 | MMP2 (0.61) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL4422501 | 0.83 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047450-B1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER LAMBERT CO (US) | 2002-10-02 | — | — | EP | disclosed |