Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.65 |
| ▸ | MMP9 | P14780 | 9/20 | 0.65 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.65 |
| ▸ | CTSL | P07711 | 4/20 | 0.59 |
| ▸ | CTSS | P25774 | 4/20 | 0.59 |
| ▸ | CTSK | P43235 | 4/20 | 0.59 |
| ▸ | CTSB | P07858 | 2/20 | 0.59 |
| ▸ | MMP13 | P45452 | 4/20 | 0.59 |
| ▸ | MMP1 | P03956 | 3/20 | 0.59 |
| ▸ | MMP3 | P08254 | 3/20 | 0.59 |
| ▸ | MMP7 | P09237 | 3/20 | 0.59 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.59 |
| ▸ | EEF2K | O00418 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615068 | 0.89 | MMP2 (0.79) | MMP2MMP9ADAMTS4CTSLCTSS | |
| SCHEMBL7615081 | 0.89 | MMP2 (0.79) | MMP2MMP9ADAMTS4CTSLCTSS | |
| SCHEMBL1920507 | 0.80 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL32691761 | 0.80 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL6545297 | 0.80 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP13MMP1 | |
| SCHEMBL7981740 | 0.78 | MMP2 (0.56) | MMP2MMP9ADAMTS4CTSLCTSS | |
| SCHEMBL16380450 | 0.77 | MMP2 (0.79) | MMP2MMP9ADAMTS4CTSLCTSS | |
| SCHEMBL2454204 | 0.76 | MMP2 (1.00) | MMP2MMP9ADAMTS4CTSLCTSS | |
| SCHEMBL32691785 | 0.76 | MMP2 (1.00) | MMP2MMP9ADAMTS4CTSLCTSS | |
| SCHEMBL28690184 | 0.76 | TDP1 (0.72) | MMP2MMP9ADAMTS4MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047450-B1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER LAMBERT CO (US) | 2002-10-02 | — | — | EP | disclosed |