Phorbol

Phorbol

SCHEMBL23610504

CC1=C[C@H]2[C@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)[C@H]([C@@H]3C=C(CO)C[C@@]2(O)C1=O)C4(C)C.CCCC(=O)O.[NaH]

nearest known ligand 0.63

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 6/20 0.61
PRKCG P05129 6/20 0.61
PRKCB P05771 5/20 0.61
PRKCH P24723 5/20 0.61
PRKCE Q02156 5/20 0.61
PRKCQ Q04759 5/20 0.61
PRKCD Q05655 5/20 0.61
PRKD3 O94806 4/20 0.61
PRKCI P41743 4/20 0.61
PRKCZ Q05513 4/20 0.61
PRKD1 Q15139 4/20 0.61
VAV1 P15498 2/20 0.61
USP2 O75604 2/20 0.54
TP53 P04637 2/20 0.54
KDM4E B2RXH2 1/20 0.54
ALDH1A1 P00352 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54
TSHR P16473 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL27450792 0.99 PRKCA (0.62) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL7615331 0.92 PRKCA (0.62) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL22973790 0.92 PRKCA (0.62) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL64353 0.92 PRKCA (0.62) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL27419386 0.92 PRKCA (0.62) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL10590327 0.91 PRKCA (0.61) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL27470489 0.91 PRKCA (0.61) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL27299282 0.91 PRKCA (0.63) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL19435231 0.91 PRKCA (0.59) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol SCHEMBL15976176 0.91 PRKCA (0.60) PRKCAPRKCGPRKCBPRKCHPRKCE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183825-A1 GAMMA HERPESVIRUS CIRCULAR RNA UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2023-06-15 US disclosed
US-20210207228-A1 GAMMA HERPESVIRUS CIRCULAR RNA UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2021-07-08 US disclosed