SCHEMBL7615568

SCHEMBL7615568

CCCC(CCc1cccc(O)c1)(COC(C)=O)NC(C)=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SPR P35270 1/20 0.40
DRD2 P14416 4/20 0.39
DRD3 P35462 3/20 0.39
DRD1 P21728 2/20 0.39
DRD4 P21917 1/20 0.39
DRD5 P21918 1/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA4 P22748 1/20 0.38
CA6 P23280 1/20 0.38
CA5A P35218 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CA5B Q9Y2D0 1/20 0.38
TYR P14679 1/20 0.38
OPRM1 P35372 2/20 0.37
OPRD1 P41143 2/20 0.37
OPRK1 P41145 2/20 0.37
GRM2 Q14416 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7622109 0.90 MAOB (0.42) ALDH1A1
SCHEMBL7622541 0.88 CYP2D6 (0.46)
SCHEMBL7622507 0.87 ALDH1A1 (0.45) ALDH1A1RECQLTAAR1
SCHEMBL7716382 0.85 MAOB (0.46) ALDH1A1
SCHEMBL7618088 0.82 SPR (0.42) SPRDRD2DRD1CA12CA1
SCHEMBL7712079 0.82 CYP2D6 (0.49)
SCHEMBL7614927 0.79 S1PR1 (0.46) ALDH1A1
SCHEMBL7613058 0.79 HTR1A (0.37) TYRALDH1A1RECQLTAAR1
SCHEMBL5035826 0.79 ALDH1A1 (0.47) ALDH1A1RECQLTAAR1
SCHEMBL5035787 0.79 ALDH1A1 (0.47) ALDH1A1RECQLTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372800-B1 IMMUNOSUPPRESSIVE EFFECT AND IS USEFUL AS AN INHIBITOR FOR THE REJECTION REACTION OCCURRING IN ORGAN OR BONE MARROW TRANSPLANTATION, AND AS A PREVENTIVE OR REMEDY FOR ARTICULAR RHEUMATISM, ATOPIC ECZEMA (DERMATITIS), BEHCET'S DISEASE, MITSUBISHI PHARMA CORPORATION (JP) 2002-04-16 US disclosed
EP-0778263-B1 BENZENE COMPOUND AND MEDICINAL USE THEREOF WELFIDE CORP (JP) 2002-01-09 EP disclosed
US-6187821-B1 SUCH AS 2-AMINO-2-(3-(4-HEPTYLPHENYL)PROPYL)BUTANE-1,4-DIOL; IMMUNOSUPPRESSANT; ADMINISTERING TO TREAT OR PREVENT AUTOIMMUNE DISEASES AND ALLERGIES WELFIDE CORPORATION (JP) 2001-02-13 US disclosed
EP-0778263-A1 BENZENE COMPOUND AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-06-11 EP disclosed