Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 15/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079757 | 0.95 | CNR2 (0.49) | CNR2HTR6CNR1MAPTALDH1A1 | |
| SCHEMBL7615399 | 0.92 | CNR2 (0.39) | CNR2HTR6MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8476032 | 0.89 | CNR2 (0.52) | CNR2HTR6CNR1MAPTALDH1A1 | |
| SCHEMBL7611927 | 0.88 | DRD2 (0.41) | CNR2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7615030 | 0.85 | KMT2A (0.39) | CNR2MAPTALDH1A1 | |
| SCHEMBL7615052 | 0.84 | KDM4E (0.39) | CNR2HTR6ALDH1A1 | |
| SCHEMBL7615408 | 0.84 | CNR2 (0.36) | CNR2HTR6CNR1MAPTALDH1A1 | |
| SCHEMBL8474347 | 0.83 | RAB9A (0.41) | CNR2CNR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7614886 | 0.83 | RAB9A (0.41) | CNR2CNR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7609464 | 0.83 | ALDH1A1 (0.42) | MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741132-B1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-5891902-A | OSTEOPOROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |