SCHEMBL762149

SCHEMBL762149

NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)C1CCNCC1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 2/20 0.49
FNTA P49354 2/20 0.49
PGGT1B P53609 2/20 0.49
SSTR4 P31391 1/20 0.43
CHRM1 P11229 1/20 0.43
CHRM3 P20309 1/20 0.43
MMP9 P14780 1/20 0.42
ULK1 O75385 1/20 0.42
HRH4 Q9H3N8 1/20 0.42
TACR1 P25103 1/20 0.41
MME P08473 1/20 0.41
ACE P12821 1/20 0.41
CPA1 P15085 1/20 0.41
ACE2 Q9BYF1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL762665 0.82 GHSR (0.71) GHSR
SCHEMBL3656798 0.82 TDP1 (0.56) FNTAPGGT1BMMP9HRH4MME
SCHEMBL8671105 0.82 TDP1 (0.56) FNTAPGGT1BMMP9HRH4MME
SCHEMBL761579 0.81 F10 (0.52) GHSRMMP9TACR1
SCHEMBL14527661 0.81 PRSS1 (0.46) GHSR
SCHEMBL10054043 0.81 CAPN1 (0.57) MMP9
SCHEMBL8671980 0.80 FNTA (0.56) FNTAPGGT1BMMP9HRH4MME
SCHEMBL8668244 0.79 FNTA (0.55) FNTAPGGT1BMMP9HRH4MME
SCHEMBL762500 0.79 GHSR (0.52) GHSRFNTAPGGT1BMMP9HRH4
SCHEMBL739284 0.75 GHSR (0.63) GHSRFNTAPGGT1BMMP9TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8138218-B2 Growth hormone secretagogues IPSEN PHARMA S.A.S. (FR) 2012-03-20 US disclosed
US-20090131478-A1 Growth Hormone Secretagogues IPSEN PHARMA S.A.S. (FR) 2009-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131478-A1 Growth Hormone Secretagogues GHSR, GHRHR, GHITM GHSR 1/4885FNTA 2002/4885PGGT1B 397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.