SCHEMBL76231

SCHEMBL76231

COc1c[c]cc(OC)c1OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.48
CA9 Q16790 2/20 0.46
CYP3A4 P08684 1/20 0.46
MAPT P10636 1/20 0.46
PTGS2 P35354 1/20 0.42
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
PDE4A P27815 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4C Q08493 1/20 0.38
PDE4D Q08499 1/20 0.38
CYP1A1 P04798 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP1B1 Q16678 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TUBB4A P04350 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL28104198 0.97 ACHE (0.46) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL27888199 0.90 CYP3A4 (0.44) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL4158740 0.85 ACHE (0.41) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL10461617 0.84 PTGS2 (0.42) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL944353 0.83 ACHE (0.34) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL1299477 0.83 MAPT (0.43) ACHECYP3A4MAPTKDM4EALDH1A1
SCHEMBL5597488 0.83 ALDH1A1 (0.38) ACHECA9CYP3A4MAPTALDH1A1
SCHEMBL943527 0.83 ALDH1A1 (0.37) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL945282 0.83 ACHE (0.34) ACHECA9CYP3A4MAPTPTGS2
SCHEMBL943918 0.83 CA2 (0.41) ACHECA9CYP3A4MAPTPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7612 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118206551-A Quinoline compounds, their preparation and their use as antimalarial agents 美国卫生和人力服务部 2024-06-18 CN claimed
CN-114891019-B Continuous flow preparation method of vinyl thioether compound 复旦大学 2024-06-04 CN claimed
CN-116102416-B Bavachin derivatives, preparation method thereof and application thereof in preparation of anticancer drugs 蚌埠医学院 2024-05-17 CN claimed
US-20240116939-A1 CHIRAL OR RACEMIC PYRIMIDINE-FUSED DIAZEPINONE DERIVATIVES, PREPARATION METHOD, AND APPLICATION THEREOF SUN YAT-SEN UNIVERSITY (CN) 2024-04-11 US claimed
EP-4346806-A2 IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE Biocryst Pharmaceuticals, Inc. (US) 2024-04-10 EP claimed
CN-117756767-A Preparation method of gamma, gamma-difluoroallylaldehyde compound and derivative thereof 南京林业大学 2024-03-26 CN claimed
CN-117603183-A 1,3-dithiane modified alpha, beta-unsaturated derivative and preparation method thereof 兰州大学 2024-02-27 CN claimed
CN-115368363-B Chiral or racemized pyrimidodiazepinone compound and preparation method and application thereof 中山大学 2024-02-20 CN claimed
CN-117529315-A Imidazole-containing ALK2 kinase inhibitors 生物水晶制药公司 2024-02-06 CN claimed
CN-117486836-A Preparation method of 2-aryl-3-carbonyl substituted tetrahydrofuran and tetrahydropyran compound 遵义医科大学 2024-02-02 CN claimed
US-3985881-A 1(3,4,5-Trimethoxybenzamido methyl) tetrahydro isoquinoline derivatives and a process for their production MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-10-12 US claimed
US-3984424-A MEDICAMENTS PFIZER INC. (US) 1976-10-05 US claimed
US-3982016-A Bone deposition by 16-aryl-13,14-dihydro-PGE2 p-biphenyl esters PFIZER INC. (US) 1976-09-21 US claimed
US-3978055-A SEDATIVE, ANTIINFLAMMATORY, VASODILATION, BRONCHODILATION DELALANDE S.A. (FR) 1976-08-31 US claimed
US-3974213-A 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins PFIZER INC. (US) 1976-08-10 US claimed
US-3965122-A ANTIALLERGENS FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-06-22 US claimed
US-3962256-A ANALGESICS, HYPOTENSIVES, ANTIINFLAMMATORY AGENTS DELALANDE S.A. (FR) 1976-06-08 US claimed
US-3953432-A OXAZOLINE DERIVATIVES COMMERCIAL SOLVENTS CORPORATION (US) 1976-04-27 US claimed
US-3947470-A CORONARY VASODILATORS, TREATMENT OF ANGINA PECTORIS SMITHKLINE CORPORATION (US) 1976-03-30 US claimed
US-3935197-A 2-Styryl-4H-pyrido(1,2-a)pyrimidin-4-ones E. R. SQUIBB & SONS, INC. (US) 1976-01-27 US claimed