Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741659 | 0.93 | PARP1 (0.42) | BRD4PARP1HPGDSP2RX7JAK2 | |
| SCHEMBL762854 | 0.87 | P2RX7 (0.42) | BRD4HPGDSP2RX7JAK2JAK1 | |
| SCHEMBL740662 | 0.81 | P2RX7 (0.41) | PARP1HPGDSP2RX7JAK2JAK1 | |
| SCHEMBL740661 | 0.81 | P2RX7 (0.41) | PARP1HPGDSP2RX7JAK2JAK1 | |
| SCHEMBL762531 | 0.78 | TLR8 (0.44) | HPGDSP2RX7MAPTTP53USP30 | |
| SCHEMBL762833 | 0.78 | POLB (0.43) | HPGDSJAK2JAK1TRPV3TP53 | |
| SCHEMBL762590 | 0.77 | P2RX7 (0.42) | PARP1HPGDSP2RX7MAPTTRPV3 | |
| SCHEMBL741975 | 0.77 | KCNH2 (0.52) | HPGDSPOLB | |
| SCHEMBL741974 | 0.77 | KCNH2 (0.52) | HPGDSPOLB | |
| SCHEMBL741590 | 0.75 | CTSB (0.35) | MAPTLMNAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |