SCHEMBL7631332

SCHEMBL7631332

O=C(O)c1cc2c(cc1Cl)OC(CCCc1ccccc1)C2

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 8/20 0.42
MTNR1B P49286 8/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7627993 0.80 TDP1 (0.52) MTNR1AMTNR1B
SCHEMBL7626734 0.79 MTNR1A (0.40) MTNR1AMTNR1B
SCHEMBL7628632 0.79 MTNR1A (0.38) MTNR1AMTNR1B
SCHEMBL7633128 0.79 GPR35 (0.51)
SCHEMBL7626493 0.78 MTNR1A (0.49) MTNR1AMTNR1B
SCHEMBL7630325 0.77 SIRT2 (0.42) MTNR1AMTNR1B
SCHEMBL10750642 0.74 SMN1; SMN2 (0.46) MTNR1AMTNR1B
SCHEMBL7634961 0.71 CYP4F2 (0.46) MTNR1AMTNR1B
SCHEMBL9727669 0.70 MTNR1A (0.43) MTNR1AMTNR1B
SCHEMBL5502112 0.70 DRD2 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888327-B1 BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION MENARINI LAB (ES) 2002-06-12 EP disclosed
US-5990142-A ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS HAVING GOOD ORAL ADSORPTION AND BIOAVAILABILITY; CARDIOTONIC AND ANTIISCHEMIC AGENTS LABORATORIOS MENARINI S.A. (ES) 1999-11-23 US disclosed
EP-0888327-A1 BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1999-01-07 EP disclosed
WO-1997034885-A1 BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-09-25 WO disclosed