Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627296 | 0.94 | MAPT (0.36) | MAPTHDAC1HDAC6CHRNB2CHRNA5 | |
| SCHEMBL7638011 | 0.84 | MAPT (0.45) | MAPTHDAC1HDAC6CHRNB2CHRNA5 | |
| SCHEMBL7244506 | 0.80 | PTGS2 (0.42) | HDAC1HDAC6KMT2AALDH1A1HPGD | |
| SCHEMBL7243350 | 0.80 | ALDH1A1 (0.46) | MAPTMAPK1KMT2AALDH1A1EPHX2 | |
| SCHEMBL7630672 | 0.78 | HDAC1 (0.42) | MAPTHDAC1HDAC6THRBEPHX2 | |
| SCHEMBL7635227 | 0.77 | CHRNB2 (0.39) | CHRNB2CHRNA5CHRNA4MAPK1KMT2A | |
| SCHEMBL7243090 | 0.77 | EPHX2 (0.42) | MAPTMAPK1KMT2AALDH1A1EPHX2 | |
| SCHEMBL7243590 | 0.77 | PTGS2 (0.39) | MAPTKMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL7635766 | 0.77 | CACNA1B (0.41) | MAPTMAPK1KMT2AALDH1A1TSHR | |
| SCHEMBL7630028 | 0.75 | ABCB1 (0.36) | MAPTMAPK1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451820-B1 | Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-09-17 | — | — | US | claimed |
| WO-2001072740-A1 | SUBSTITUTED 1-(4-AMINOPHENYL) TRIAZOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | WO | claimed |