Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30670479 | 0.80 | KDM4E (0.37) | NOS2KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL29364256 | 0.75 | DHFR (0.40) | KDM4EMAPKAPK2SIRT2 | |
| SCHEMBL1317507 | 0.75 | ALDH1A1 (0.36) | KDM4ESIRT2 | |
| SCHEMBL1474541 | 0.75 | DHFR (0.40) | KDM4EMAPKAPK2SIRT2 | |
| SCHEMBL30976556 | 0.72 | TKT (0.38) | SIRT2 | |
| SCHEMBL30605673 | 0.71 | NOS2 (0.36) | NOS2 | |
| SCHEMBL15124112 | 0.71 | NOS2 (0.36) | NOS2 | |
| SCHEMBL26122204 | 0.70 | NR4A2 (0.40) | NOS2 | |
| SCHEMBL28783446 | 0.69 | GABRA5 (0.41) | KDM4EHSD17B10 | |
| SCHEMBL22781437 | 0.68 | KDM4E (0.67) | NOS2KDM4EUSP2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020111355-A1 | Cyclic urea and cyclic amide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-08-15 | — | — | US | disclosed |
| US-6399593-B1 | CONTRACEPTIVES | WYETH | 2002-06-04 | — | — | US | disclosed |
| CN-1349537-A | Cyclic urea and cyclic amide derivatives | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1349412-A | Cyclic therapy using cyclic urea and cyclic amide derivatives | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| US-6369056-B1 | AGONISTS AND ANTAGONISTS OF THE PROGESTERONE RECEPTOR; CONTRACEPTIVES; 6-(3-CHLOROPHENYL)-4,4-DIMETHYL-1,4-DIHYDRO -3-OXA-1,8-DIAZA-NAPHTHALENE-2-ONE AND 6-CHLORO-4,4-DIMETHYL-1,4-DIHYDRO-3-OXA-1,5-DIAZA-NAPHTHALEN-2-ONE | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-09 | — | — | US | disclosed |
| EP-1173443-A1 | CYCLIC UREA AND CYCLIC AMIDE DERIVATIVES | American Home Products Corporation (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1173208-A2 | CONTRACEPTIVE COMPOSITIONS CONTAINING CYCLIC UREA AND AMIDE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066103-A2 | CONTRACEPTIVE COMPOSITIONS CONTAINING CYCLIC UREA AND AMIDE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000066592-A1 | CYCLIC UREA AND CYCLIC AMIDE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111355-A1 | Cyclic urea and cyclic amide derivatives | PGR, GNRHR, FSHR | NOS2 1582/4885KDM4E 2894/4885USP2 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.