SCHEMBL7640359

SCHEMBL7640359

CCCCC(Br)c1ccc(C)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.45
PTGES O14684 2/20 0.37
ALOX5 P09917 2/20 0.37
PPARG P37231 2/20 0.37
PPARA Q07869 1/20 0.37
CHRNA7 P36544 1/20 0.35
HTT P42858 1/20 0.35
BDKRB2 P30411 1/20 0.33
SLC2A1 P11166 1/20 0.33
ACHE P22303 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP17A1 P05093 1/20 0.33
NPC1 O15118 1/20 0.33
TSHR P16473 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CYP19A1 P11511 1/20 0.33
CA12 O43570 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9789948 0.87 CHRNA7 (0.38) HRH3ALOX5CHRNA7ACHETDP1
SCHEMBL28771612 0.85 BDKRB2 (0.47) HRH3PTGESALOX5PPARGPPARA
SCHEMBL5795845 0.83 CYP1A2 (0.38) ALOX5BDKRB2TDP1NPC1RAB9A
SCHEMBL6683571 0.82 HTR7 (0.39) SMN1; SMN2
SCHEMBL28771738 0.82 BDKRB2 (0.40) HRH3BDKRB2SLC2A1ACHETDP1
SCHEMBL4059571 0.82 ESR1 (0.52) ACHETDP1ALDH1A1
SCHEMBL7217195 0.82 SLC6A2 (0.44) TDP1TSHRSMN1; SMN2CA2CA9
SCHEMBL1920593 0.81 POLB (0.45) CYP19A1ALDH1A1
SCHEMBL28771735 0.80 LTA4H (0.44) HTTSLC2A1NPC1RAB9ASMN1; SMN2
SCHEMBL28771985 0.80 MCL1 (0.36) HRH3PTGESALOX5PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016132134-A1 THIAZOLE DERIVATIVES FOR THE TREATMENT OF ANIMAL TRYPANOSOMIASIS UNIVERSITY OF DUNDEE (GB) 2016-08-25 WO disclosed
EP-1021438-A4 TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES HAUSER INC (US) 2002-08-28 EP disclosed
EP-1021438-A1 TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES Hauser, Inc. (US) 2000-07-26 EP disclosed
WO-1998024786-A9 TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES 1998-10-08 WO disclosed
WO-1998024786-A1 TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES HAUSER, INC. (US) 1998-06-11 WO disclosed