SCHEMBL7644191

SCHEMBL7644191

C[C]=Nc1c(Cl)cccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.38
CYP2A6 P11509 2/20 0.38
TSHR P16473 2/20 0.36
LMNA P02545 2/20 0.36
GABRA1 P14867 2/20 0.35
GABRB2 P47870 2/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPT P10636 1/20 0.35
ALDH1A1 P00352 4/20 0.34
HTR3E A5X5Y0 1/20 0.32
HTR3B O95264 1/20 0.32
HTR3A P46098 1/20 0.32
HTR3D Q70Z44 1/20 0.32
HTR3C Q8WXA8 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
KCNH2 Q12809 1/20 0.31
PNMT P11086 2/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27818899 0.87 MEN1 (0.35) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL8734575 0.79 CYP1A2 (0.41) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL11652732 0.76 CYP1A2 (0.35) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL894400 0.75 GABRA1 (0.54) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL22081583 0.75 CYP1A2 (0.38) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL326586 0.75 GABRA1 (0.56) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL27988436 0.75 CYP1A2 (0.38) CYP1A2CYP2A6TSHRLMNAGABRA1
SCHEMBL7640017 0.73 ALDH1A1 (0.32) TSHRALDH1A1
SCHEMBL1547641 0.70 CYP1A2 (0.43) CYP1A2CYP2A6TSHRLMNAHSP90AA1
SCHEMBL20049740 0.70 ALDH1A1 (0.32) CYP1A2CYP2A6HSP90AA1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002083749-A2 METHOD FOR TRANSITION METAL-CATALYZED PRODUCTION OF AQUEOUS DISPERSIONS CONTAINING POLYOLEFINS OR VINYL AROMATIC POLYMERS BASF AKTIENGESELLSCHAFT (DE) 2002-10-24 WO disclosed