SCHEMBL7644429

SCHEMBL7644429

C[Ti](C)([SiH3])(Cl)(Cl)(NC(=O)C1CCCCC1)C1C=C(c2ccccc2)c2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.38
ADORA1 P30542 3/20 0.37
CCKAR P32238 1/20 0.37
CCKBR P32239 1/20 0.37
GAA P10253 1/20 0.36
ADORA2A P29274 2/20 0.36
ADORA3 P0DMS8 2/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
ALOX12 P18054 1/20 0.35
LMNA P02545 1/20 0.34
P2RX7 Q99572 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8523064 0.75
SCHEMBL7630771 0.74 CYP2C19 (0.40) ALDH1A1HPGDCYP2C19GAAMEN1
SCHEMBL2033385 0.71 CYP2C19 (0.43) ALDH1A1HPGDCYP2C19CCKARCCKBR
Hydrochloric Acid SCHEMBL7644423 0.70 ALDH1A1 (0.41) ALDH1A1HPGDCYP2C19ADORA1CCKAR
SCHEMBL7753151 0.65 NPC1 (0.40) ALDH1A1HPGDCYP2C19GAAMEN1
SCHEMBL38659461 0.61 ALDH1A1 (0.94) ALDH1A1HPGDCYP2C19ADORA1ADORA2A
SCHEMBL911084 0.60 CYP2A6 (0.33) ALDH1A1
SCHEMBL2039752 0.59 CYP2C19 (0.43) ALDH1A1HPGDCYP2C19HDAC1HDAC2
Bicarbonate SCHEMBL27568262 0.58 PTGS2 (0.60) ALDH1A1GAAMEN1KMT2ALMNA
Biphenyl SCHEMBL8962449 0.58 RAB9A (0.61) ALDH1A1HPGDADORA1ADORA2AADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946574-B1 3-ARYL SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND POLYMERIZATION PROCESS DOW CHEMICAL CO (US) 2002-02-13 EP claimed
US-5866704-A 3-aryl substituted indenyl containing metal complexes and polymerization process THE DOW CHEMICAL COMPANY (US) 1999-02-02 US claimed