SCHEMBL7645845

SCHEMBL7645845

CNCCc1ccccc1OCCO

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 3/20 0.54
TP53 P04637 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
TAAR1 Q96RJ0 3/20 0.51
LMNA P02545 1/20 0.51
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.45
HTR1B P28222 2/20 0.45
HTR1D P28221 1/20 0.45
SLC6A4 P31645 2/20 0.44
SLC6A2 P23975 1/20 0.43
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7648488 0.92 HRH1 (0.56) HRH1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL2909676 0.85 HRH1 (0.55) HRH1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL2910225 0.83 HRH1 (0.58) HRH1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL13894378 0.83 ALDH1A1 (0.42) HRH1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL8504979 0.82 MTNR1A (0.55) KDM4EALDH1A1MTNR1AMTNR1B
SCHEMBL10335287 0.82 ALDH1A1 (0.48) L3MBTL1LMNAALDH1A1
SCHEMBL8284011 0.81 MTNR1A (0.68) L3MBTL1KDM4EALDH1A1MTNR1AMTNR1B
SCHEMBL3057074 0.81 L3MBTL1 (0.53) HRH1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL73790 0.81 PPARD (0.54) L3MBTL1ALDH1A1
SCHEMBL8284758 0.80 MTNR1B (0.55) KDM4EALDH1A1MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923539-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2002-06-05 EP disclosed
EP-1184370-A2 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2002-03-06 EP disclosed
US-6274584-B1 PEPTIDE DERIVATIVES; BIOAVAILABILITY; ENZYME RESISTANCE; MILK AND WOOL PRODUCTION NOVO NORDISK A/S (DK) 2001-08-14 US disclosed
US-6127354-A FOR TREATMENT OF GROWTH DISORDERS OR TO STIMULATE PRODUCTION OF WOOL OR MILK NOVO NORDISK A/S (DK) 2000-10-03 US disclosed
US-5922770-A NOVEL COMPOUNDS THAT STIMULATE THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY NOVO NORDISK A/S (DK) 1999-07-13 US disclosed
EP-0923539-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1999-06-23 EP disclosed
WO-1998003473-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1998-01-29 WO disclosed