Phosphocholine

Phosphocholine

SCHEMBL7646155

C[N+](C)(C)CCOP(=O)([O-])[O-].[Ca+2].[Cl-]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phosphocholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.52
AKT1 P31749 2/20 0.52
ADRA1A P35348 2/20 0.52
ESR1 P03372 1/20 0.52
ADORA3 P0DMS8 1/20 0.52
CDC25A P30304 1/20 0.52
AGTR1 P30556 1/20 0.52
KCNH2 Q12809 1/20 0.52
SMN1; SMN2 Q16637 4/20 0.47
CHRM5 P08912 4/20 0.40
CHRM1 P11229 4/20 0.40
CHRM3 P20309 4/20 0.40
BLM P54132 2/20 0.40
MAPT P10636 1/20 0.40
PRKD3 O94806 1/20 0.40
PRKCG P05129 1/20 0.40
PRKCB P05771 1/20 0.40
PRKCA P17252 1/20 0.40
PRKCH P24723 1/20 0.40
PRKCI P41743 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphocholine SCHEMBL5330902 0.98 LMNA (0.50) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL10717808 0.98 LMNA (0.53) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL7174376 0.98 LMNA (0.53) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL18192302 0.95 LMNA (0.55) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL9447039 0.95 LMNA (0.55) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL9447079 0.93 LMNA (0.53) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL9447028 0.93 LMNA (0.53) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL9335813 0.85 SMN1; SMN2 (0.51) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL15525300 0.82 SMN1; SMN2 (0.45) LMNAAKT1ADRA1AESR1ADORA3
Phosphocholine SCHEMBL3485572 0.81 CHRM5 (0.68) LMNAAKT1ADRA1AESR1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119955879-A Method for synthesizing citicoline by biological enzyme 拓新药业集团股份有限公司 2025-05-09 CN claimed
CN-117551147-A Synthetic method of citicoline 成都市海通药业有限公司 2024-02-13 CN claimed
US-11503337-B2 Method and apparatus of video coding HFI INNOVATION INC. (TW) 2022-11-15 US claimed
CN-108610359-B Preparation method of phosphorylcholine chloride calcium salt 山东奥博生物科技有限公司 2020-05-29 CN claimed
US-5500668-A INK JET PRINTING XEROX CORPORATION (US) 1996-03-19 US claimed
JP-57108099-A None JP disclosed
JP-57108098-A None JP disclosed
JP-62004207-A None JP disclosed
EP-4683640-A1 NOVEL PHOSPHATE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF Samant, Rajaram (IN) 2026-01-28 EP disclosed
WO-2024194891-A1 NOVEL PHOSPHATE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF SAMANT RAJARAM (IN) 2024-09-26 WO disclosed
CN-117551147-A Synthetic method of citicoline 成都市海通药业有限公司 2024-02-13 CN disclosed
CN-113816991-B Preparation method of choline calcium chloride phosphate 拓新药业集团股份有限公司 2023-12-15 CN disclosed
CN-103694271-A Preparation method of calcium phosphorylcholine chloride CHANGSHU FUSHILAI MEDICINE & CHEMICAL CO LTD 2014-04-02 CN disclosed
US-6350795-B1 ACOUSTIC PHASE-CHANGE CONDUCTIVE INK CONTAINING LOW MOLECULAR WEIGHT OXYALKYLENE SEGMENTS COMPLEXED WITH UREA DERIVATIVES XEROX CORPORATION 2002-02-26 US disclosed
US-6171702-B1 Coated substrates XEROX CORPORATION 2001-01-09 US disclosed
US-6096125-A Ink compositions XEROX CORPORATION (US) 2000-08-01 US disclosed
US-5500668-A INK JET PRINTING XEROX CORPORATION (US) 1996-03-19 US disclosed
JP-S624207-A ROOTING PROMOTER FOR CUTTING MITSUBISHI GAS CHEM CO INC 1987-01-10 JP disclosed
JP-S57108099-A PREPARATION OF CHOLINE CYTIDINE DIPHOSPHATE KOHJIN CO LTD 1982-07-05 JP disclosed
JP-S57108098-A PREPARATION OF CHOLINE CYTIDINE DIPHOSPHATE KOHJIN CO LTD 1982-07-05 JP disclosed