Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 4/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 7/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27913942 | 0.81 | ABCC8 (0.33) | ABCC8KCNJ11EPAS1VEGFAKIF11 | |
| SCHEMBL3556690 | 0.76 | ALDH1A1 (0.34) | EPAS1KIF11ARALDH1A1SIRT6 | |
| SCHEMBL301080 | 0.76 | TDP1 (0.34) | ALDH1A1TDP1 | |
| SCHEMBL18478 | 0.73 | TSHR (0.42) | ALDH1A1TDP1 | |
| SCHEMBL1995800 | 0.72 | TDP1 (0.46) | ABCC8KCNJ11EPAS1VEGFAKIF11 | |
| SCHEMBL9789548 | 0.72 | ALDH1A1 (0.42) | ALDH1A1TDP1 | |
| SCHEMBL3047388 | 0.72 | GPR35 (0.46) | ALDH1A1TDP1 | |
| SCHEMBL6514635 | 0.71 | AR (0.38) | KIF11ARALDH1A1SIRT6TDP1 | |
| SCHEMBL11690136 | 0.69 | ALDH1A1 (0.33) | ALDH1A1TDP1 | |
| SCHEMBL10731966 | 0.69 | ALDH1A1 (0.39) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486153-B1 | Phenylindole derivatives as 5-HT2A receptor ligands | MERCK SHARP & DOHME LTD. | 2002-11-26 | — | — | US | disclosed |
| WO-1999011619-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |