Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.35 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378519 | 0.83 | CYP1A2 (0.36) | CYP1A2CYP2D6CYP2C19L3MBTL1POLB | |
| SCHEMBL6294806 | 0.81 | POLB (0.33) | ALDH1A1GAAPROKR1FPR2CYP1A2 | |
| SCHEMBL939579 | 0.81 | CYP1A2 (0.35) | CYP1A2CYP2D6CYP2C19L3MBTL1POLB | |
| SCHEMBL757178 | 0.79 | CYP2C19 (0.48) | ALDH1A1GAACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5373012 | 0.78 | ALDH1A1 (0.34) | ALDH1A1GAAPROKR1FPR2CYP1A2 | |
| SCHEMBL5373017 | 0.78 | ALDH1A1 (0.34) | ALDH1A1GAAPROKR1FPR2CYP1A2 | |
| SCHEMBL5372979 | 0.78 | POLB (0.35) | ALDH1A1GAAPROKR1FPR2CYP1A2 | |
| SCHEMBL5372975 | 0.78 | POLB (0.35) | ALDH1A1GAAPROKR1FPR2CYP1A2 | |
| SCHEMBL14507097 | 0.77 | CYP2C19 (0.38) | ALDH1A1GAACYP1A2CYP2D6CYP2C19 | |
| Formamide SCHEMBL5345806 | 0.76 | POLB (0.36) | ALDH1A1PROKR1FPR2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411431-A1 | Novel compounds and their use in therapy | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-12-29 | — | — | US | disclosed |
| US-11466011-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-10-11 | — | — | US | disclosed |
| EP-3313833-B1 | COMPOUNDS AND THEIR USE AS INHIBITORS OF N-MYRISTOYL TRANSFERASE | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2021-01-06 | — | — | EP | disclosed |
| US-20200339586-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2020-10-29 | — | — | US | disclosed |
| US-20200339586-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2020-10-29 | — | — | US | disclosed |
| US-10759804-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| US-10759804-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| US-20180370974-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-12-27 | — | — | US | disclosed |
| CN-101861312-B | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-HT7 receptor antagonists | LILLY CO ELI | 2014-09-03 | — | — | CN | disclosed |
| EP-2155717-B1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-10-24 | — | — | EP | disclosed |
| US-8202873-B2 | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines as 5-HT7 receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-06-19 | — | — | US | disclosed |
| EP-2050745-B1 | N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT | OTSUKA AGRITECHNO CO LTD (JP) | 2012-03-21 | — | — | EP | disclosed |
| CN-101243049-B | Substituted pyrazolecarboxylic acid anilide derivative or salt thereof, intermediate thereof, agent for agricultural and horticultural use, and use thereof | NIHON NOHYAKU CO LTD | 2011-11-16 | — | — | CN | disclosed |
| CN-101861312-A | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-HT7 receptor antagonists | LILLY CO ELI | 2010-10-13 | — | — | CN | disclosed |
| US-20100120785-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-05-13 | — | — | US | disclosed |
| EP-2155717-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141020-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2008-11-20 | — | — | WO | disclosed |
| CN-101243049-A | Substituted pyrazolecarboxylic acid anilide derivative or salt thereof, intermediate thereof, agent for agricultural and horticultural use, and use thereof | NIHON NOHYAKU CO LTD (JP) | 2008-08-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759804-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | NMT1, NMT2, GNMT | ALDH1A1 4471/4885GAA 580/4885PROKR1 4050/4885 |
| US-20220411431-A1 | Novel compounds and their use in therapy | NMT1, NMT2, FNTA | ALDH1A1 4270/4885GAA 526/4885PROKR1 3244/4885 |
| US-11466011-B2 | Compounds and their use as inhibitors of N-myristoyl transferase | NMT1, NMT2, GNMT | ALDH1A1 4471/4885GAA 580/4885PROKR1 4050/4885 |
| US-20180370974-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | NMT1, NMT2, GNMT | ALDH1A1 4471/4885GAA 580/4885PROKR1 4050/4885 |
| US-20100120785-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | HTR7, HTR2C, HTR4 | ALDH1A1 1205/4885GAA 4789/4885PROKR1 401/4885 |
| US-20200339586-A1 | Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase | NMT1, NMT2, GNMT | ALDH1A1 4471/4885GAA 580/4885PROKR1 4050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.