Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986225 | 0.85 | ALDH1A1 (0.46) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL8986224 | 0.85 | ALDH1A1 (0.46) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL18775920 | 0.83 | POLB (0.46) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL1445933 | 0.78 | ADRB2 (0.43) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14928501 | 0.77 | L3MBTL1 (0.52) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14928880 | 0.77 | L3MBTL1 (0.52) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14928965 | 0.77 | ADRB2 (0.50) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL12625516 | 0.77 | KMT2A (0.40) | L3MBTL1KMT2AMEN1PKMCA1 | |
| SCHEMBL8446208 | 0.76 | PRKCA (0.52) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14929732 | 0.76 | L3MBTL1 (0.51) | ADRB2ADRB1ADRB3L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118093-B1 | [1,2,3]TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK CANADA INC (CA) | 2012-03-21 | — | — | EP | disclosed |
| WO-2008095292-A1 | [1,2,3] TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA LTD. (CA) | 2008-08-14 | — | — | WO | disclosed |