Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764762 | 0.78 | ADRB2 (0.47) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL4950521 | 0.73 | ALDH1A1 (0.55) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14928501 | 0.72 | L3MBTL1 (0.52) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14928880 | 0.72 | L3MBTL1 (0.52) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14928965 | 0.72 | ADRB2 (0.50) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL18983684 | 0.72 | ADRB2 (0.47) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL8446208 | 0.71 | PRKCA (0.52) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL14929732 | 0.71 | L3MBTL1 (0.51) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL17702640 | 0.71 | CES2 (0.51) | ADRB2ADRB1ADRB3L3MBTL1ATM | |
| SCHEMBL4809726 | 0.71 | ALDH1A1 (0.60) | ADRB2ADRB1ADRB3L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480547-A2 | INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE | Panmira Pharmaceuticals, LLC (US) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011109679-A2 | INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011038086-A2 | INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2011-03-31 | — | — | WO | disclosed |