Chloromethane

Chloromethane

SCHEMBL7649372

CCl.Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 10/20 0.75
MMP9 P14780 10/20 0.75
ADAMTS4 O75173 1/20 0.75
ALDH1A1 P00352 1/20 0.74
MAPT P10636 1/20 0.74
TDP1 Q9NUW8 1/20 0.74
ADAMTS5 Q9UNA0 1/20 0.70
POLB P06746 1/20 0.70
MMP1 P03956 1/20 0.67
MMP3 P08254 1/20 0.67
MMP7 P09237 1/20 0.67
MMP13 P45452 1/20 0.67
CTSL P07711 1/20 0.59
CA2 P00918 1/20 0.59
CA7 P43166 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697477 0.97 MMP2 (0.79) MMP2MMP9ADAMTS4ALDH1A1MAPT
SCHEMBL1203540 0.97 MMP2 (0.79) MMP2MMP9ADAMTS4ALDH1A1MAPT
SCHEMBL697476 0.97 MMP2 (0.79) MMP2MMP9ADAMTS4ALDH1A1MAPT
SCHEMBL3856155 0.96 MMP2 (0.73) MMP2MMP9ADAMTS4ALDH1A1MAPT
Hydrochloric Acid SCHEMBL3839410 0.96 MMP2 (0.77) MMP2MMP9ADAMTS4ALDH1A1MAPT
Hydrochloric Acid SCHEMBL11133046 0.96 MMP2 (0.77) MMP2MMP9ADAMTS4ALDH1A1MAPT
SCHEMBL561565 0.95 MMP2 (0.71) MMP2MMP9ADAMTS4ALDH1A1MAPT
SCHEMBL433897 0.95 MMP2 (0.71) MMP2MMP9ADAMTS4ALDH1A1MAPT
Hydrochloric Acid SCHEMBL28872216 0.95 MMP2 (0.75) MMP2MMP9ADAMTS4ALDH1A1MAPT
SCHEMBL433895 0.92 MMP9 (0.69) MMP2MMP9ADAMTS4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6414115-B1 NUCLEOTIDE AND AMINO ACID SEQUENCE OF PROTEIN ISOLATED FROM DIROFILARIA IMMITIS; NEMATOCIDES; LARVICIDES; VETERINARY MEDICINE HESKA CORPORATION 2002-07-02 US disclosed
US-6383774-B1 NUCLEOTIDE SEQUENCES; NEMATOCIDES; PARASITICIDES; RECOMBINANT CULTURE PRODUCTION OF ENZYME; VETERINARY MEDICINE HESKA CORPORATION 2002-05-07 US disclosed
CN-1326782-A About human digestive enzyme recombined protein and its preparing method ASTRA AB (SE) 2001-12-19 CN disclosed
US-6309644-B1 Parasitic nematode transglutaminase proteins and uses thereof HESKA CORPORATION 2001-10-30 US disclosed
US-6248872-B1 NUCLEOTIDE SEQUENCES WHICH CODE ENZYMATIC PROTEIN; FOR USE IN DETECTION AND TREATMENT OF DIROFILARIA INFECTION HESKA CORPORATION 2001-06-19 US disclosed
US-6165735-A Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof HESKA CORPORATION 2000-12-26 US disclosed
US-6042825-A A PARASITIC HELMINTH ASPARAGINASE PROTEINS; PARASITIC HELMINTH ASPARAGINASE NUCLEIC ACID MOLECULES THAT CODES SUCH ASPARAGINASE PROTEINS HESKA CORPORATION (US) 2000-03-28 US disclosed
EP-0950092-A2 PARASITIC NEMATODE TRANSGLUTAMINASE PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF Heska Corporation (US) 1999-10-20 EP disclosed
WO-1999014339-A1 ASPARAGINASE PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF OBTAINABLE FROM A PARASITIC HELMINTH, IN PARTICULAR FROM $i(DIROFILARIA IMMITIS) HESKA CORPORATION (US) 1999-03-25 WO disclosed
US-5854051-A Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof HESKA CORPORATION (US) 1998-12-29 US disclosed
WO-1998024887-A2 PARASITIC NEMATODE TRANSGLUTAMINASE PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF HESKA CORPORATION (US) 1998-06-11 WO disclosed
EP-0535048-B1 USE OF DERIVATIVES OF HUMAN BILE-SALT STIMULATED LIPASE FOR THE PREPARATION OF MEDICAMENTS ASTRA AB (SE) 1997-04-02 EP disclosed