Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 5/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952644 | 0.79 | TDP2 (0.44) | LMNATSHRALDH1A1TDP1TDP2 | |
| SCHEMBL29945643 | 0.78 | DPP7 (0.50) | LMNATSHRALDH1A1TDP1TDP2 | |
| SCHEMBL7657931 | 0.76 | DPP7 (0.41) | LMNATDP2DPP7PNMTADRA2A | |
| SCHEMBL29558059 | 0.74 | ADRA2A (0.51) | LMNAALDH1A1PNMTADRA2AL3MBTL1 | |
| SCHEMBL324724 | 0.74 | ADRA2A (0.51) | LMNAALDH1A1PNMTADRA2AL3MBTL1 | |
| SCHEMBL7656239 | 0.73 | NR1H2 (0.35) | LMNAALDH1A1ADRA2CMAPTMEN1 | |
| SCHEMBL5917126 | 0.73 | CA1 (0.47) | LMNATSHRALDH1A1TDP1TDP2 | |
| Hydrochloric Acid SCHEMBL7832321 | 0.73 | ADRA2A (0.50) | LMNAALDH1A1PNMTADRA2AL3MBTL1 | |
| SCHEMBL8607529 | 0.73 | MAPT (0.46) | LMNAALDH1A1TDP1DPP7MAPT | |
| SCHEMBL25339488 | 0.73 | SIRT6 (0.44) | LMNAALDH1A1TDP1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |
| EP-1104404-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009486-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSIVANTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-24 | — | — | WO | disclosed |