Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594739 | 0.91 | NOTUM (0.61) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 | |
| Hydrochloric Acid SCHEMBL7651017 | 0.85 | ENPP2 (0.49) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 | |
| SCHEMBL7657342 | 0.82 | CA1 (0.52) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 | |
| SCHEMBL7660151 | 0.81 | CYP1A2 (0.38) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL7007424 | 0.79 | CYP3A4 (0.69) | NOTUMCYP3A4CYP2D6LMNAMAPT | |
| SCHEMBL7658197 | 0.78 | ALOX15 (0.53) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 | |
| SCHEMBL7650969 | 0.78 | ALOX15 (0.53) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 | |
| SCHEMBL8779793 | 0.76 | ALDH1A1 (0.52) | CYP3A4LMNAMAPTMEN1TSHR | |
| SCHEMBL10423949 | 0.76 | ENPP2 (0.59) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 | |
| SCHEMBL4408673 | 0.76 | CHRNA7 (0.76) | NOTUMCYP3A4CHRNA7CYP2D6PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |