SCHEMBL10423949

SCHEMBL10423949

O=S(=O)(O)c1ccc(-n2ccnc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.59
MKNK1 Q9BUB5 1/20 0.59
MKNK2 Q9HBH9 1/20 0.59
CYP3A4 P08684 3/20 0.56
BAZ2B Q9UIF8 1/20 0.56
CHRNA7 P36544 1/20 0.55
LMNA P02545 1/20 0.55
MAPT P10636 1/20 0.55
NOTUM Q6P988 1/20 0.55
ADH5 P11766 1/20 0.53
MEN1 O00255 1/20 0.51
ALOX15 P16050 1/20 0.51
TSHR P16473 1/20 0.51
KMT2A Q03164 1/20 0.51
HTT P42858 1/20 0.51
CYP2D6 P10635 1/20 0.51
PSEN1 P49768 1/20 0.51
PSEN2 P49810 1/20 0.51
APH1B Q8WW43 1/20 0.51
NCSTN Q92542 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7657456 0.91 CA1 (0.51) ENPP2MKNK1MKNK2CYP3A4BAZ2B
Hydrochloric Acid SCHEMBL7657350 0.89 CA1 (0.52) ENPP2MKNK1MKNK2CYP3A4BAZ2B
Hydrochloric Acid SCHEMBL7651017 0.89 ENPP2 (0.49) ENPP2MKNK1MKNK2CYP3A4BAZ2B
SCHEMBL5310306 0.87 ADH5 (0.63) ENPP2MKNK1MKNK2CYP3A4BAZ2B
Hydrochloric Acid SCHEMBL7650974 0.86 ADH5 (0.51) ENPP2MKNK1MKNK2CYP3A4BAZ2B
Hydrochloric Acid SCHEMBL7658202 0.86 ADH5 (0.51) ENPP2MKNK1MKNK2CYP3A4BAZ2B
SCHEMBL9594739 0.84 NOTUM (0.61) ENPP2MKNK1MKNK2CYP3A4BAZ2B
SCHEMBL4408673 0.82 CHRNA7 (0.76) ENPP2MKNK1MKNK2CYP3A4BAZ2B
SCHEMBL8797691 0.82 MAOA (0.61) ENPP2MKNK1MKNK2CYP3A4BAZ2B
SCHEMBL2532397 0.80 LMNA (0.78) ENPP2MKNK1MKNK2CYP3A4BAZ2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4904564-A PHENOLIC-FORMALDEHYDE NOVOLAK; DIAZO SENSITIZER; IMIDAZOLE, BENZIMIDAZOLE, TRIAZOLE OR INDAZOLE TO INCREASE SOLUBILITY INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1990-02-27 US disclosed
EP-0139090-B1 PROCESS FOR THE PRE-TREATMENT OF POLYIMIDES SCHERING AKTIENGESELLSCHAFT (DE) 1988-07-27 EP disclosed
US-4517254-A ALKALI METAL HYDROXIDE, AMINOALKYLPOLYACID COMPOUNT SCHERING AKTIENGESELLSCHAFT (DE) 1985-05-14 US disclosed
EP-0139090-A1 Process for the pre-treatment of polyimides SCHERING AKTIENGESELLSCHAFT (DE) 1985-05-02 EP disclosed
US-4248632-A ACTIVATION OF A POLYMER SURFACE WITH A PALLADIUM COMPLEX SALT SCHERING AKTIENGESELLSCHAFT (DE) 1981-02-03 US disclosed