Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.76 |
| ▸ | CA1 | P00915 | 4/20 | 0.67 |
| ▸ | CA2 | P00918 | 4/20 | 0.67 |
| ▸ | CA9 | Q16790 | 4/20 | 0.67 |
| ▸ | CA12 | O43570 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23088859 | 0.87 | CHRNA7 (1.00) | CHRNA7CA1CA2CA9CA12 | |
| SCHEMBL23088860 | 0.87 | CHRNA7 (1.00) | CHRNA7CA1CA2CA9CA12 | |
| SCHEMBL9594739 | 0.84 | NOTUM (0.61) | CHRNA7CA1CA2CA9CA12 | |
| SCHEMBL8797691 | 0.82 | MAOA (0.61) | CHRNA7CA1CA2CA9CA12 | |
| SCHEMBL10423949 | 0.82 | ENPP2 (0.59) | CHRNA7CA1CA2CA9CA12 | |
| SCHEMBL8797045 | 0.80 | IDO1 (0.59) | CHRNA7CA1CA2CA9CA12 | |
| SCHEMBL2532397 | 0.80 | LMNA (0.78) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL9451337 | 0.78 | CA2 (0.66) | CHRNA7CA1CA2CA9LMNA | |
| Hydrochloric Acid SCHEMBL28701756 | 0.78 | LMNA (0.75) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL6514849 | 0.78 | PTGS2 (0.73) | CA1CA2CA9CA12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040998-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20200109164-A1 | BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARM INC (US) | 2020-04-09 | — | — | US | disclosed |
| US-10457703-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20160289262-A1 | BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2016-10-06 | — | — | US | disclosed |
| US-20160289262-A1 | BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2016-10-06 | — | — | US | disclosed |
| US-8476456-B2 | Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives | PALAU PHARMA, S.A. (ES) | 2013-07-02 | — | — | US | disclosed |
| US-8476456-B2 | Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives | PALAU PHARMA, S.A. (ES) | 2013-07-02 | — | — | US | disclosed |
| US-8476456-B2 | Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives | PALAU PHARMA, S.A. (ES) | 2013-07-02 | — | — | US | disclosed |
| US-20090012307-A1 | Process for the Preparation of 4-(imidazol-1-yl)benzenesulfonamide Derivatives | PALAU PHARMA, S.A. (ES) | 2009-01-08 | — | — | US | disclosed |
| US-20090012307-A1 | Process for the Preparation of 4-(imidazol-1-yl)benzenesulfonamide Derivatives | PALAU PHARMA, S.A. (ES) | 2009-01-08 | — | — | US | disclosed |
| US-7351836-B2 | Antiinflammatory agents | PALAU PHARMA, S.A. (ES) | 2008-04-01 | — | — | US | disclosed |
| US-7351836-B2 | Antiinflammatory agents | PALAU PHARMA, S.A. (ES) | 2008-04-01 | — | — | US | disclosed |
| US-7351836-B2 | Antiinflammatory agents | PALAU PHARMA, S.A. (ES) | 2008-04-01 | — | — | US | disclosed |
| US-20040242872-A1 | Method of preparing 4-(imidazole-1-yl)benzenesulphonamide derivatives | PALAU PHARMA, S.A. (ES) | 2004-12-02 | — | — | US | disclosed |
| US-20040242872-A1 | Method of preparing 4-(imidazole-1-yl)benzenesulphonamide derivatives | PALAU PHARMA, S.A. (ES) | 2004-12-02 | — | — | US | disclosed |
| US-20040242872-A1 | Method of preparing 4-(imidazole-1-yl)benzenesulphonamide derivatives | PALAU PHARMA, S.A. (ES) | 2004-12-02 | — | — | US | disclosed |
| EP-1424329-A1 | METHOD OF PREPARING 4-(IMIDAZOLE-1-IL)BENZENESULPHONAMIDE DERIVATIVES | J. Uriach & Cia. S.A. (ES) | 2004-06-02 | — | — | EP | disclosed |
| EP-1424329-A1 | METHOD OF PREPARING 4-(IMIDAZOLE-1-IL)BENZENESULPHONAMIDE DERIVATIVES | J. Uriach & Cia. S.A. (ES) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003016285-A8 | METHOD OF PREPARING 4-(IMIDAZOLE-1-IL)BENZENESULPHONAMIDE DERIVATIVES | URIACH & CIA SA J (ES) | 2003-08-28 | — | — | WO | disclosed |
| WO-2003016285-A1 | METHOD OF PREPARING 4-(IMIDAZOLE-1-IL)BENZENESULPHONAMIDE DERIVATIVES | J. URIACH & CIA. S.A. (ES) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040998-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | GPBAR1, NR1H4, SLC10A1 | CHRNA7 2654/4885CA1 1773/4885CA2 1361/4885 |
| US-20090012307-A1 | Process for the Preparation of 4-(imidazol-1-yl)benzenesulfonamide Derivatives | IL1B, IL1A, TBXAS1 | CHRNA7 4505/4885CA1 4776/4885CA2 4485/4885 |
| US-20040242872-A1 | Method of preparing 4-(imidazole-1-yl)benzenesulphonamide derivatives | IL1B, IL1A, IRAK1 | CHRNA7 4561/4885CA1 4607/4885CA2 4236/4885 |
| US-20160289262-A1 | BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF | GPBAR1, NR1H4, SLC10A1 | CHRNA7 2654/4885CA1 1773/4885CA2 1361/4885 |
| US-20200109164-A1 | BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF | GPBAR1, NR1H4, SLC10A1 | CHRNA7 2654/4885CA1 1773/4885CA2 1361/4885 |
| US-10457703-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | GPBAR1, NR1H4, SLC10A1 | CHRNA7 2654/4885CA1 1773/4885CA2 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.