Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648338 | 0.85 | FEN1 (0.45) | FEN1NPC1SMN1; SMN2DAOKDM4E | |
| SCHEMBL7650006 | 0.82 | FEN1 (0.58) | FEN1DAO | |
| SCHEMBL7652236 | 0.80 | SMN1; SMN2 (0.55) | FEN1GAANPC1SMN1; SMN2ADORA3 | |
| SCHEMBL7651849 | 0.78 | MPO (0.38) | GAANPC1SMN1; SMN2DAOADORA3 | |
| SCHEMBL7651932 | 0.76 | FEN1 (0.51) | FEN1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7653151 | 0.74 | KDM4E (0.44) | GAANPC1SMN1; SMN2ADORA3KDM4E | |
| SCHEMBL30970862 | 0.74 | FEN1 (0.60) | FEN1SMN1; SMN2DAOADORA3KDM4E | |
| SCHEMBL7653163 | 0.73 | SMN1; SMN2 (0.54) | NPC1SMN1; SMN2KDM4EALDH1A1TSHR | |
| SCHEMBL7649595 | 0.73 | KDM4E (0.47) | GAANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10507746 | 0.72 | FEN1 (0.66) | FEN1DAOADORA3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |