SCHEMBL7653151

SCHEMBL7653151

CCOC(=O)C(C)(C)n1c(=O)[nH]c2cc3ccccc3cc2c1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.44
ALDH1A1 P00352 5/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
GAA P10253 3/20 0.44
NPC1 O15118 3/20 0.44
MAPT P10636 3/20 0.44
LMNA P02545 2/20 0.44
HPGD P15428 2/20 0.44
MEN1 O00255 2/20 0.44
RAB9A P51151 2/20 0.44
KMT2A Q03164 2/20 0.44
GLA P06280 1/20 0.44
ATM Q13315 1/20 0.44
ADORA3 P0DMS8 2/20 0.40
HSD17B10 Q99714 5/20 0.38
MAT2A P31153 1/20 0.37
USP2 O75604 1/20 0.37
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
TUBB4A P04350 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7648323 0.85 SMN1; SMN2 (0.41) KDM4EALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL7652236 0.85 SMN1; SMN2 (0.55) KDM4EALDH1A1SMN1; SMN2GAANPC1
SCHEMBL7649595 0.83 KDM4E (0.47) KDM4EALDH1A1SMN1; SMN2GAANPC1
SCHEMBL7651849 0.83 MPO (0.38) KDM4EALDH1A1SMN1; SMN2GAANPC1
SCHEMBL7651163 0.82 LMNA (0.44) KDM4EALDH1A1LMNAHPGDADORA3
SCHEMBL7651842 0.81 CA12 (0.51) KDM4EALDH1A1SMN1; SMN2GAANPC1
SCHEMBL7648344 0.81 CA9 (0.51) KDM4EGAAHPGDHSD17B10USP2
SCHEMBL7651932 0.81 FEN1 (0.51) KDM4EALDH1A1SMN1; SMN2MAPTLMNA
SCHEMBL7649684 0.81 CA12 (0.51) ALDH1A1SMN1; SMN2MAPTLMNAHPGD
SCHEMBL7651738 0.80 SMN1; SMN2 (0.43) KDM4EALDH1A1SMN1; SMN2GAANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407116-B1 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS TAKEDA CHEMICAL INDUSTRIES, INC. (JP) 2002-06-18 US disclosed
EP-1026160-A1 NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS Takeda Chemical Industries, Ltd. (JP) 2000-08-09 EP disclosed