Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 2/20 | 0.51 |
| ▸ | MPO | P05164 | 4/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GALR2 | O43603 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649595 | 0.88 | KDM4E (0.47) | DDR1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7651842 | 0.86 | CA12 (0.51) | MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7649684 | 0.86 | CA12 (0.51) | DDR1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7651849 | 0.85 | MPO (0.38) | MPOXDHKMT2ALMNAMAPT | |
| SCHEMBL7650012 | 0.84 | MPO (0.44) | FEN1MPOXDHKMT2AMAPT | |
| SCHEMBL7652236 | 0.83 | SMN1; SMN2 (0.55) | FEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7650104 | 0.82 | FEN1 (0.58) | FEN1MPOXDHDDR1KMT2A | |
| SCHEMBL7657940 | 0.82 | CA12 (0.55) | KMT2ALMNAMAPTMEN1ALDH1A1 | |
| SCHEMBL7651738 | 0.82 | SMN1; SMN2 (0.43) | KMT2AMAPTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7653151 | 0.81 | KDM4E (0.44) | KMT2ALMNAMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |