Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374022 | 0.87 | RAB9A (0.74) | RAB9ANPC1CHEK1KDRFLT3 | |
| SCHEMBL29631691 | 0.87 | RAB9A (0.74) | RAB9ANPC1CHEK1KDRFLT3 | |
| Phosphoric Acid SCHEMBL18344261 | 0.80 | FLT3 (0.48) | RAB9ANPC1CHEK1KDRFLT3 | |
| SCHEMBL2993551 | 0.78 | FLT3 (0.50) | RAB9ANPC1CHEK1KDRFLT3 | |
| SCHEMBL29628104 | 0.78 | FLT3 (0.50) | RAB9ANPC1CHEK1KDRFLT3 | |
| SCHEMBL7980702 | 0.77 | NPC1 (0.44) | RAB9ANPC1CHEK1KDRFLT3 | |
| Phosphoric Acid SCHEMBL30909011 | 0.76 | KDM4E (0.56) | FLT3KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL5051826 | 0.76 | KDR (0.68) | RAB9ANPC1CHEK1KDRFLT3 | |
| SCHEMBL5053299 | 0.76 | NPC1 (0.87) | RAB9ANPC1CHEK1KDRKDM4E | |
| SCHEMBL11498132 | 0.75 | KDM4E (0.72) | RAB9ANPC1CHEK1KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468503-B2 | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer | ONCOLOGIC, INC. | 2002-10-22 | — | — | US | disclosed |