Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.36 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647968 | 0.76 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2PKMIDO1MAPT | |
| SCHEMBL16334693 | 0.71 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2PKMMAPTALOX5 | |
| SCHEMBL17045908 | 0.71 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2PKMMAPTGAA | |
| SCHEMBL7355822 | 0.70 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2PKMIDO1MAPT | |
| SCHEMBL8003157 | 0.70 | CYP2C19 (0.64) | ALDH1A1SMN1; SMN2PKMIDO1GAA | |
| SCHEMBL530979 | 0.70 | PDE4B (0.54) | ALDH1A1SMN1; SMN2PKMGAAEPHX1 | |
| SCHEMBL7604958 | 0.69 | EPHX1 (0.43) | ALDH1A1SMN1; SMN2IDO1ALOX5GAA | |
| SCHEMBL17045933 | 0.69 | HDAC1 (0.59) | ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL7651583 | 0.68 | ALOX5 (0.41) | ALDH1A1SMN1; SMN2PKMIDO1ALOX5 | |
| SCHEMBL9043314 | 0.68 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2PKMIDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212096-A2 | DRUG CONJUGATES AND METHODS OF DESIGNING THE SAME | Brenner, Sydney (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001013958-A2 | DRUG CONJUGATES AND METHODS OF DESIGNING THE SAME | BRENNER SYDNEY (US) | 2001-03-01 | — | — | WO | disclosed |