Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 4/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 9/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.34 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.34 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.34 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.34 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.34 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121197 | 0.92 | DDR2 (0.41) | DDR2BDKRB1RAF1BRAFMEN1 | |
| SCHEMBL765827 | 0.90 | BDKRB1 (0.39) | DDR2BDKRB1ROS1ALKPSMB11 | |
| SCHEMBL765838 | 0.89 | P2RX7 (0.40) | DDR2BDKRB1RAF1EPHX2 | |
| SCHEMBL764459 | 0.85 | GRM2 (0.45) | DDR2BDKRB1ROS1ALKPSMB11 | |
| SCHEMBL765640 | 0.85 | SCN9A (0.38) | DDR2BDKRB1PSMB11PSMA7PSMB1 | |
| SCHEMBL13165721 | 0.85 | HTRA1 (0.36) | DDR2BDKRB1RAF1ROS1ALK | |
| SCHEMBL13904206 | 0.85 | BDKRB1 (0.39) | DDR2BDKRB1PSMB11PSMA7PSMB1 | |
| SCHEMBL764440 | 0.85 | SCD (0.37) | DDR2BDKRB1ROS1ALKPSMB11 | |
| SCHEMBL764434 | 0.85 | DDR2 (0.38) | DDR2BDKRB1ROS1ALKPSMB11 | |
| SCHEMBL764500 | 0.84 | BDKRB1 (0.43) | BDKRB1PSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |