Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998552 | 0.89 | CYP3A4 (0.50) | CLK4LMNAKDM4ECYP3A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7653109 | 0.83 | CLK4 (0.47) | CLK4LMNAKDM4ECYP3A4HTT | |
| SCHEMBL433497 | 0.81 | HTT (0.58) | LMNAHTTALDH1A1HSD17B10TDP1 | |
| SCHEMBL9720036 | 0.81 | HTT (0.58) | LMNAHTTALDH1A1HSD17B10TDP1 | |
| SCHEMBL9539212 | 0.80 | ALDH1A1 (0.56) | LMNAKDM4EHTTALDH1A1HSD17B10 | |
| SCHEMBL7892614 | 0.80 | SOS1 (0.58) | LMNAKDM4EHTTALDH1A1HSD17B10 | |
| SCHEMBL7657519 | 0.79 | HTT (0.44) | LMNAKDM4ECYP3A4HTTALDH1A1 | |
| SCHEMBL31244 | 0.77 | SOS1 (0.64) | LMNAKDM4EHTTALDH1A1HSD17B10 | |
| SCHEMBL9536733 | 0.77 | SOS1 (0.64) | LMNAKDM4EHTTALDH1A1HSD17B10 | |
| SCHEMBL7014701 | 0.77 | CLK4 (0.61) | CLK4ALDH1A1TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |