Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1656016 | 0.90 | MMP1 (0.50) | HTTALDH1A1MMP1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4027206 | 0.89 | MMP1 (0.49) | HTTALDH1A1MMP1LMNAMAPT | |
| SCHEMBL2331077 | 0.88 | MAPT (0.52) | ALDH1A1LMNAMAPTCYP3A4CYP2D6 | |
| SCHEMBL433497 | 0.84 | HTT (0.58) | HTTALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9720036 | 0.84 | HTT (0.58) | HTTALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7649535 | 0.83 | PTGS2 (0.56) | HTTALDH1A1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL9539212 | 0.83 | ALDH1A1 (0.56) | HTTALDH1A1MMP1LMNASMN1; SMN2 | |
| SCHEMBL7892614 | 0.83 | SOS1 (0.58) | HTTALDH1A1MMP1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7657523 | 0.82 | MMP1 (0.44) | HTTALDH1A1MMP1LMNAMAPT | |
| SCHEMBL7649531 | 0.82 | CYP3A4 (0.43) | HTTALDH1A1LMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |