Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650555 | 0.90 | ALDH1A1 (0.35) | ALDH1A1TNFTSHRSMN1; SMN2MEN1 | |
| SCHEMBL7651131 | 0.89 | CNR2 (0.42) | ALDH1A1TNFMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7654909 | 0.88 | POLB (0.40) | ALDH1A1TNFMAPTPOLBSMN1; SMN2 | |
| SCHEMBL7650485 | 0.87 | HDAC1 (0.38) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7649498 | 0.87 | HDAC6 (0.40) | ALDH1A1TNFPSEN1PSEN2APH1B | |
| SCHEMBL7651760 | 0.87 | PTGDR2 (0.40) | MEN1KMT2ACNR2 | |
| SCHEMBL7651764 | 0.81 | ALDH1A1 (0.35) | ALDH1A1TNFTSHRSMN1; SMN2MEN1 | |
| SCHEMBL7651781 | 0.80 | KCNA3 (0.39) | ALDH1A1TNFMAPTPOLBSMN1; SMN2 | |
| SCHEMBL7655134 | 0.76 | TNF (0.51) | ALDH1A1TNFHTTCNR2 | |
| SCHEMBL7652234 | 0.76 | CNR2 (0.49) | ALDH1A1TNFMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |