Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650485 | 0.90 | HDAC1 (0.38) | SMN1; SMN2PTGDR2ALDH1A1L3MBTL1CNR2 | |
| SCHEMBL7651760 | 0.90 | PTGDR2 (0.40) | PTGDR2CNR2KMT2A | |
| SCHEMBL7651131 | 0.90 | CNR2 (0.42) | SMN1; SMN2ALDH1A1L3MBTL1CNR2KDM4E | |
| SCHEMBL7653503 | 0.88 | ALDH1A1 (0.37) | POLBSMN1; SMN2ALDH1A1CNR2HTT | |
| SCHEMBL7651232 | 0.88 | RORA (0.41) | POLBSMN1; SMN2PGRRORARORC | |
| SCHEMBL7650555 | 0.87 | ALDH1A1 (0.35) | SMN1; SMN2NPC1RAB9AALDH1A1CNR2 | |
| SCHEMBL7649498 | 0.85 | HDAC6 (0.40) | SMN1; SMN2ALDH1A1L3MBTL1CNR2KDM4E | |
| SCHEMBL7651764 | 0.80 | ALDH1A1 (0.35) | SMN1; SMN2NPC1RAB9AALDH1A1CNR2 | |
| SCHEMBL7655134 | 0.80 | TNF (0.51) | NPC1ALDH1A1L3MBTL1CNR2KDM4E | |
| SCHEMBL7651781 | 0.79 | KCNA3 (0.39) | POLBSMN1; SMN2ALDH1A1L3MBTL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |