Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650555 | 0.90 | ALDH1A1 (0.35) | CNR2KMT2AMEN1LMNAGAA | |
| SCHEMBL7654909 | 0.90 | POLB (0.40) | PTGDR2CNR2KMT2A | |
| SCHEMBL7650485 | 0.89 | HDAC1 (0.38) | PTGDR2CNR2HDAC1HDAC6KMT2A | |
| SCHEMBL7651131 | 0.89 | CNR2 (0.42) | CNR2KMT2AMEN1LMNA | |
| SCHEMBL7653503 | 0.87 | ALDH1A1 (0.37) | CNR2KMT2AMEN1 | |
| SCHEMBL7654237 | 0.87 | PER2 (0.38) | PTGDR2CNR2ACACBPER2LMNA | |
| SCHEMBL7649498 | 0.84 | HDAC6 (0.40) | CNR2HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL7651764 | 0.83 | ALDH1A1 (0.35) | CNR2KMT2AMEN1LMNAGAA | |
| SCHEMBL7651781 | 0.82 | KCNA3 (0.39) | CNR2KMT2AMEN1GAA | |
| SCHEMBL7651232 | 0.77 | RORA (0.41) | CNR2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |