Hesperetin

Hesperetin

SCHEMBL765368

COc1ccc(C2CC(=O)c3c(O)cc(O)cc3O2)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 1.00
CYP1A1 P04798 6/20 1.00
CYP1A2 P05177 6/20 1.00
CYP1B1 Q16678 6/20 1.00
CYP3A4 P08684 5/20 1.00
TP53 P04637 3/20 1.00
CA12 O43570 3/20 1.00
CA4 P22748 3/20 1.00
CYP2C19 P33261 3/20 1.00
CA7 P43166 3/20 1.00
HSD17B10 Q99714 3/20 1.00
MAPT P10636 3/20 1.00
ALDH1A1 P00352 3/20 1.00
XDH P47989 2/20 1.00
HPGD P15428 2/20 1.00
PKM P14618 2/20 1.00
MAPK1 P28482 2/20 1.00
CYP2C9 P11712 2/20 1.00
DPP4 P27487 2/20 1.00
GSK3B P49841 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hesperetin SCHEMBL6422865 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL5202121 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL29534477 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL29359052 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL39833 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL30696626 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL29484563 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL31689737 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL20929082 1.00 CYP19A1 (1.00) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4
Hesperetin SCHEMBL28595598 0.99 CYP19A1 (0.98) CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210290514-A1 An Antimicrobial Combination Composition Comprising Glycerol Derivatives and Bicyclic Compounds SACHEM EUROPE B.V. (NL) 2021-09-23 US claimed
CN-112955113-A Antimicrobial binding compositions comprising glycerol derivatives and bicyclic compounds 科莱恩国际有限公司 2021-06-11 CN claimed
EP-3817712-A1 AN ANTIMICROBIAL COMBINATION COMPOSITION COMPRISING GLYCEROL DERIVATIVES AND BICYCLIC COMPOUNDS Clariant International Ltd (CH) 2021-05-12 EP claimed
WO-2020007571-A1 AN ANTIMICROBIAL COMBINATION COMPOSITION COMPRISING GLYCEROL DERIVATIVES AND BICYCLIC COMPOUNDS CLARIANT INTERNATIONAL LTD (CH) 2020-01-09 WO claimed
US-20180042962-A1 Vascular Calcification Prevention and Treatment Summit Innovation Labs LLC (US) 2018-02-15 US claimed
US-20170027902-A1 Use of a Composition Comprising a Flavonol, A Flavonoid, and a Fatty Acid in the Treatment of Oxidative Injuries Due to Mitochondrial Dysfunction ROBERTSON, GEORGE (CA) 2017-02-02 US claimed
WO-2015154192-A1 USE OF A COMPOSITION COMPRISING A FLAVONOL, A FLAVONOID, AND A FATTY ACID IN THE TREATMENT OF OXIDATIVE INJURIES DUE TO MITOCHONDRIAL DYSFUNCTION ROBERTSON GEORGE (CA) 2015-10-15 WO claimed
EP-0290442-A4 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. CHEMEX PHARMACEUTICALS INC (US) 1990-07-03 EP claimed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP claimed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO claimed
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US claimed
US-4214963-A Process for the preparation of substituted 4H-pyran-4-ones Garcia de Lama, Javier (ES) 1980-07-29 US claimed
US-20250312392-A1 MICROBIAL COMPOSITIONS TO INCREASE THE PRODUCTION OF PCA FROM POLYPHENOLS CHURCH & DWIGHT CO., INC. (US) 2025-10-09 US disclosed
US-12364718-B2 Microbial compositions to increase the production of PCA from polyphenols CHURCH & DWIGHT CO., INC. (US) 2025-07-22 US disclosed
US-20250114424-A1 PLANT EXTRACT-BASED COMPOSITION AND ITS USE FOR TREATING GLUCOSE METABOLISM DISORDERS ESSERRE PHARMA SRL (IT) 2025-04-10 US disclosed
US-20250090435-A1 PRESERVATIVES FOR COSMETIC AND PHARMACEUTICAL COMPOSITIONS SACHEM, INC. (US) 2025-03-20 US disclosed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP disclosed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO disclosed
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US disclosed
EP-0065123-B1 HARDLY SOLUBLE SALTS OF AMINOGLYCOSIDE ANTIBIOTICS MERCK PATENT GmbH (DE) 1984-07-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210290514-A1 An Antimicrobial Combination Composition Comprising Glycerol Derivatives and Bicyclic Compounds GK, MGLL, UGCG CYP19A1 1248/4885CYP1A1 2314/4885CYP1A2 2206/4885
US-20250090435-A1 PRESERVATIVES FOR COSMETIC AND PHARMACEUTICAL COMPOSITIONS PLOD2, CUTA, PHOSPHO1 CYP19A1 49/4885CYP1A1 137/4885CYP1A2 130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.