Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 9/20 | 0.34 |
| ▸ | MMP9 | P14780 | 6/20 | 0.34 |
| ▸ | MMP2 | P08253 | 5/20 | 0.34 |
| ▸ | MMP12 | P39900 | 5/20 | 0.34 |
| ▸ | MMP14 | P50281 | 4/20 | 0.34 |
| ▸ | MMP15 | P51511 | 4/20 | 0.34 |
| ▸ | MMP16 | P51512 | 4/20 | 0.34 |
| ▸ | MMP26 | Q9NRE1 | 4/20 | 0.34 |
| ▸ | MMP7 | P09237 | 4/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.33 |
| ▸ | MMP8 | P22894 | 3/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654948 | 0.89 | MMP1 (0.38) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| SCHEMBL7658355 | 0.87 | ESR1 (0.39) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| SCHEMBL7661855 | 0.87 | ESR1 (0.39) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| SCHEMBL7651679 | 0.86 | KDM4E (0.44) | LMNATSHRMMP1MMP9MMP2 | |
| SCHEMBL7674837 | 0.81 | MMP1 (0.40) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| SCHEMBL7651141 | 0.81 | MMP1 (0.40) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| Hydrochloric Acid SCHEMBL7654884 | 0.81 | ADH5 (0.42) | TSHR | |
| SCHEMBL7659859 | 0.80 | LMNA (0.39) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| SCHEMBL7654894 | 0.80 | LMNA (0.41) | LMNASMN1; SMN2TSHRHTTMMP1 | |
| SCHEMBL7659469 | 0.80 | LMNA (0.39) | LMNASMN1; SMN2TSHRHTTMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |