Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | ADH5 | P11766 | 1/20 | 0.39 |
| ▸ | PORCN | Q9H237 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661855 | 1.00 | ESR1 (0.39) | ESR1CYP19A1ESR2ADH5PORCN | |
| SCHEMBL7654948 | 0.97 | MMP1 (0.38) | ESR1CYP19A1ESR2CYP2D6MMP1 | |
| Hydrochloric Acid SCHEMBL7654884 | 0.94 | ADH5 (0.42) | ESR1CYP19A1ESR2ADH5PORCN | |
| SCHEMBL7651679 | 0.90 | KDM4E (0.44) | ESR1CYP19A1ESR2ADH5CYP3A4 | |
| SCHEMBL7674837 | 0.88 | MMP1 (0.40) | MMP1LMNASMN1; SMN2TSHRHTT | |
| SCHEMBL7651141 | 0.88 | MMP1 (0.40) | MMP1LMNASMN1; SMN2TSHRHTT | |
| SCHEMBL7659207 | 0.87 | CHRNA7 (0.36) | ESR1CYP19A1ESR2ADH5PORCN | |
| SCHEMBL7654117 | 0.87 | LMNA (0.35) | MMP1LMNASMN1; SMN2TSHRHTT | |
| SCHEMBL7659859 | 0.87 | LMNA (0.39) | MMP1LMNASMN1; SMN2TSHRHTT | |
| SCHEMBL7656362 | 0.86 | PSEN1 (0.41) | ESR1CYP19A1CYP3A4CYP2D6MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |