Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CPN1 | P15169 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5466349 | 1.00 | LMNA (0.59) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL5466344 | 1.00 | LMNA (0.59) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL11595350 | 0.87 | LMNA (0.70) | LMNAHIF1AGALR3ADRB2SLC6A3 | |
| SCHEMBL9158456 | 0.84 | CPN1 (0.45) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL15178195 | 0.84 | CPN1 (0.45) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL9158459 | 0.84 | CPN1 (0.45) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL6257483 | 0.82 | TSHR (0.45) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL10635780 | 0.81 | TSHR (0.47) | LMNACPN1CPB2CYP3A4RECQL | |
| SCHEMBL20032392 | 0.81 | CYP3A4 (0.46) | LMNACPN1CPB2CYP3A4CASP1 | |
| SCHEMBL2238144 | 0.81 | CPN1 (0.49) | LMNACPN1CPB2CYP3A4CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020143043-A1 | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-10-03 | — | — | US | disclosed |
| CN-1054418-A | For with relate to (S)-go improvement of first fluoxetine | LILLY CO ELI (US) | 1991-09-11 | — | — | CN | disclosed |
| CN-1042704-A | FLUOXETINE ANALOG | LILLY CO ELI (US) | 1990-06-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143043-A1 | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them | VCAM1, ITGA1, ITGA4 | LMNA 1503/4885CPN1 4861/4885CPB2 3384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.