Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 4/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.43 |
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534936 | 0.91 | P2RY2 (0.43) | P2RY6P2RY2ADKADORA3LMNA | |
| SCHEMBL21998920 | 0.89 | ADK (0.52) | P2RY6P2RY2ADKADORA3LMNA | |
| SCHEMBL1684799 | 0.89 | ADK (0.52) | P2RY6P2RY2ADKADORA3LMNA | |
| SCHEMBL234387 | 0.85 | LMNA (0.46) | P2RY6P2RY2ADKADORA3LMNA | |
| SCHEMBL21999788 | 0.83 | ADK (0.40) | P2RY6P2RY2ADKADORA3ALDH1A1 | |
| SCHEMBL3504116 | 0.83 | FBP1 (0.57) | P2RY6P2RY2P2RY4 | |
| SCHEMBL14946157 | 0.83 | FBP1 (0.57) | P2RY6P2RY2P2RY4 | |
| SCHEMBL17809090 | 0.83 | FBP1 (0.57) | P2RY6P2RY2P2RY4 | |
| SCHEMBL903054 | 0.83 | FBP1 (0.57) | P2RY6P2RY2P2RY4 | |
| SCHEMBL5955214 | 0.83 | ADORA3 (0.45) | P2RY6ADORA3LMNAMTORTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002531378-A | — | — | 2002-09-24 | — | — | JP | claimed |
| EP-1071699-A4 | ENHANCED ANTISENSE MODULATION OF ICAM-1 | ISIS PHARMACEUTICALS INC (US) | 2002-05-29 | — | — | EP | claimed |
| EP-1071699-A1 | ENHANCED ANTISENSE MODULATION OF ICAM-1 | ISIS PHARMACEUTICALS, INC. (US) | 2001-01-31 | — | — | EP | claimed |
| WO-1999054341-A1 | ENHANCED ANTISENSE MODULATION OF ICAM-1 | ISIS PHARMACEUTICALS, INC. (US) | 1999-10-28 | — | — | WO | claimed |