Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | S100B | P04271 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CD44 | P16070 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514568 | 0.87 | CD44 (0.46) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| SCHEMBL8421108 | 0.80 | HSD17B10 (0.35) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| SCHEMBL7101456 | 0.79 | MMP2 (0.50) | ALDH1A1TDP1L3MBTL1HSD17B10HPGD | |
| SCHEMBL6472907 | 0.78 | CYP3A4 (0.52) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| SCHEMBL4636717 | 0.76 | S100B (0.48) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| Hydrochloric Acid SCHEMBL6472903 | 0.76 | CYP3A4 (0.50) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| Hydrochloric Acid SCHEMBL3385173 | 0.76 | CYP3A4 (0.50) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| SCHEMBL10700706 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP3A4TSHRTDP1PSMD14 | |
| SCHEMBL9695883 | 0.74 | ALDH1A1 (0.64) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL50190 | 0.73 | ALDH1A1 (0.43) | ALDH1A1CYP3A4TSHRTDP1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-1033366-A2 | Amide derivatives useful as Neuropeptide Y (NPY) antagonists | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |